Albuquerque, New Mexico
Along the banks of the Rio Grande, with the Sandia Mountains in the background, is the beautiful city of Albuquerque, N.M. The sunny climate and endless landscape have long drawn writers, poets, and artists to this spot, which includes an unconventional mix of American Indian, Hispanic, and Anglo cultures. But it's not just freethinkers who drift to this Southwestern city of 511,000. Kirtland Air Force Base, Sandia National Laboratories, and Intel Corp. have helped develop the area into a manufacturing and research hub. They provide a stable anchor for the local economy.

Auburn, Alabama
For Southern charm with collegiate vigor, consider Auburn, Ala. This diamond on the eastern Alabama plains has a population of just under 50,000 and is home to Auburn University. On football Saturdays, when die-hard fans arrive in droves to cheer their beloved Tigers, Auburn swells to the state's fifth-most-populous city. And as Auburn's largest employer, the university also plays a starring role in the local economy.

La Crosse, Wisconsin
With a population of about 50,000, La Crosse, Wis., is a great staging ground for exploring the natural wonders of the upper Mississippi River area. Although winters can be bitterly cold, friendly Midwesterners and the nearby ski slopes will keep your spirits high. The spring opens an active outdoor culture of camping, hiking, hunting, and fishing that brings more than a million visitors to the area each year. Explore the mighty Mississippi on a riverboat tour, or try your luck with the northern pike in Lake Onalaska. "Great people, fun town," says Dave Lueck, a 36-year-old graduate student at the University of Wisconsin-La Crosse. "It's not too big, not too small." And with a 2008 median home sale price of $113,000, it's also an affordable destination.

Austin, Texas
If you're a free spirit, music junkie, or barbecue lover—or if you simply have what it takes to "keep Austin weird"—Texas's state capital is for you. Considered ground zero for live music, this city of 716,000 residents is home to legions of musicians and nearly 200 performance venues. In addition, Austin hosts the always popular South by Southwest festival. Since its inception in 1987, the event has mushroomed from a local gathering to a 1,800-band, 80-stage extravaganza of music, filmmaking, and interactive activities featuring performers from all over the world. Austin is also a high-tech hub, with companies like Dell and IBM, which employ thousands of residents.

Boise, Idaho
Although often overlooked, Boise, Idaho, is a terrific destination for those looking to escape out West. With a high-desert climate of sunshine, clear skies, and four distinct seasons, this city of 200,000 makes a perfect base camp for exploring southwest Idaho's dramatic panorama. Choose from the many nearby parks, which total some 2,700 acres, cast a fishing line into the Boise River, or head over to Boise State University for a Broncos football game.

Durham, North Carolina
Once a tobacco town, Durham, N.C., has evolved into a world-class center of all things advanced. This city of 206,000, located halfway between the Atlantic coast and the Great Smoky Mountains, is called the "City of Medicine" because of its expansive healthcare industry. And although widely known as the home of prestigious Duke University, it's also a thriving technology hub. At the same time, Durham's mild climate allows residents to get out and explore the region's abundant outdoor attractions. Consider hiking one of the many distinct trails and greenways or heading over to the Durham Bulls Athletic Park for an afternoon baseball game.

Loveland, Colorado
Located just outside the breathtaking Rocky Mountain National Park, Loveland, Colo., is considered the "Gateway to the Rockies." But while it has 27 public parks and nearly 16 miles of recreation trails, it's Loveland's affection for man-made beauty that sets this community of 56,000 residents apart. Thanks to its Art in Public Places program, more than 300 pieces of sculpture and two-dimensional works are on display throughout the community. And with a 2008 median home sale price of $186,000, the area's real estate market is relatively affordable.

San Luis Obispo, California
Tucked into California's sweeping Central Coast region is lovely San Luis Obispo, Calif. Its warm, gentle climate, with temperatures rarely surpassing 90 degrees, is perfect for hitting nearby beaches or touring local vineyards. In addition, California Polytechnic State University, which is located in town, infuses the community with intellectual energy.

St. Augustine, Florida
As the nation's longest continually inhabited European-founded city, St. Augustine, Fla., considers itself the oldest city in the United States. Founded in 1565 by Spanish Adm. Pedro Menéndez de Avilés, this community of 13,000 residents on Florida's northeastern coast has managed to maintain its colonial charm. Take the Castillo de San Marcos, for example. This remarkable stone-and-mortar fort is located right in the heart of St. Augustine's cobblestoned historic district. And even though 300 years of violent storms and enemy firepower couldn't penetrate its walls, visitors can enter the 20.5-acre monument site today for just $6.

Upper St. Clair, Pennsylvania
For a quiet residential option, consider Upper St. Clair, Pa. This quaint town of fewer than 20,000 residents is located in the hilly woodlands outside Pittsburgh, where the Whiskey Rebellion of the late 1700s was centered. The median home price of this family-oriented community was $240,000 in 2008. And its school system is superb: Ninety-eight percent of its high school graduates go on to college, and the Upper St. Clair school district currently boasts 10 federal government blue-ribbon "Excellence in Education" awards.

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